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Potential effect of enalapril on clomipramine metabolism
Author(s) -
Toutoungi M.
Publication year - 1992
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470070509
Subject(s) - clomipramine , enalapril , medicine , blood pressure , antidepressant , imipramine , tricyclic antidepressant , pharmacology , anesthesia , endocrinology , angiotensin converting enzyme , hippocampus , pathology , alternative medicine
In two patients treated for hypertension with enalapril for more than 12 months, clomipramine was introduced in small to moderate doses for the treatment of dysthymic disorders. Rapid improvement of depressive symptoms was noted, which was followed by signs of antidepressant overdosage. The blood levels of clomipramine and desmethylchlomipramine were high. After reducing the dose, the symptoms resolved and the blood level of antidepressant returned to the usual therapeutic range. Enalapril would appear to reduce the clearance of clomipramine; the association enalapril + clomipramine does not appear to modify blood pressure.