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Rapid lithiumization in acute manic patients
Author(s) -
Moscovich D. G.,
Shapira B.,
Lerer B.,
Belmaker R. H.
Publication year - 1992
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470070508
Subject(s) - lithium (medication) , mania , psychopathology , medicine , lithium therapy , pharmacokinetics , bipolar disorder , psychiatry
Nine patients with acute mania were treated with high‐dose lithium therapy and daily blood level monitoring for the first 3 days of treatment. Rapid reduction in psychopathology was seen. It is possible that the delay of 7–10 days in clinical response to usual lithium treatment may be partially pharmacokinetic, and that high‐dose lithium loading at the onset of treatment of mania may reduce the need for neuroleptic co‐treatment.