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The effect of vigabatrin on cognitive function and mood
Author(s) -
Dijkstra J. B.,
McGuire A. M.,
Trimble M. R.
Publication year - 1992
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470070504
Subject(s) - vigabatrin , mood , beck depression inventory , psychology , cognition , depression (economics) , epilepsy , clinical psychology , psychiatry , anticonvulsant , medicine , anesthesia , anxiety , economics , macroeconomics
Cognitive function and mood have been assessed in nine patients started on vigabatrin as additional therapy to their regular anticonvulsants. Psychological tests were given at baseline (S1) and at 4 weeks (S2) after starting treatment. A comparison group of nine patients on stable therapy was tested at the same time intervals. In particular, tasks with minimal or no motor components were used. Mood was rated with the Beck Depression Inventory. The vigabatrin group scored significantly higher on a task of attention and concentration at S2. This was not related to change of seizure frequency or serum levels of other anticonvulsants. No effects were observed on mood.