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A comparison of the effect of lofepramine, maprotiline and placebo on information processing in healthy volunteers
Author(s) -
Hopes H.,
Wandmacher J.
Publication year - 1992
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470070305
Subject(s) - maprotiline , placebo , crossover study , medicine , audiology , anesthesia , psychiatry , anxiety , alternative medicine , antidepressant , pathology
Single oral doses of lofepramine (140 mg), maprotiline (100 mg), and placebo were administered in a randomized three‐way crossover design with 1 week wash‐out between administrations to 12 healthy male volunteers. Before, and 1, and 3 h post‐administration a battery of performance tests was administered which included a digit‐matching paradigm and a reaction test separating recognition and motor time. In contrast to maprotiline, lofepramine did not impair speed and accuracy of cognitive performance.