A comparison of the effect of lofepramine, maprotiline and placebo on information processing in healthy volunteers

Single oral doses of lofepramine (140 mg), maprotiline (100 mg), and placebo were administered in a randomized three‐way crossover design with 1 week wash‐out between administrations to 12 healthy male volunteers. Before, and 1, and 3 h post‐administration a battery of performance tests was administered which included a digit‐matching paradigm and a reaction test separating recognition and motor time. In contrast to maprotiline, lofepramine did not impair speed and accuracy of cognitive performance.