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Variation in platelet [ 3 H]imipramine binding during the menstrual cycle in healthy young women
Author(s) -
Ellis Peter M.,
McIntosh C. Joy,
Cooke Russell R.
Publication year - 1992
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470070107
Subject(s) - menstrual cycle , imipramine , endocrinology , medicine , platelet , depression (economics) , atypical depression , menstruation , hormone , appetite , economics , macroeconomics , alternative medicine , pathology
Abstract Platelet [ 3 H]imipramine binding, a putative biological marker for depression, varies considerably among healthy control subjects. This study examined whether changes associated with the menstrual cycle could account for part of this variability. No significant relationship was found between B max or K d and the phase of the menstrual cycle, or symptoms associated with the premenstrual syndrome or progesterone or oestradiol levels. Other factors should be considered in exploring the variability of[ 3 H]imipramine binding in healthy subjects.