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Clinical significance of 5‐HT uptake inhibitors
Author(s) -
Montgomery S. A.
Publication year - 1991
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470060502
Subject(s) - antidepressant , tricyclic , depression (economics) , anxiety , placebo , medicine , clinical efficacy , tricyclic antidepressant , pharmacology , psychiatry , psychology , alternative medicine , pathology , economics , macroeconomics
The antidepressant efficacy of some of the newer 5‐HT uptake inhibitors is reviewed on the basis of the available data. The placebo controlled evidence of efficacy of the 5‐HT uptake inhibitors as a class is substantial with a broad range of antidepressant action and apparent equivalent efficacy to reference tricyclic antidepressants. Some selective advantage in treating anxiety or suicidal thoughts associated with depression is noted and the growing evidence of a unique selective role in treating obsessive compulsive disorder with or without depression is commented on.