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Effects of alcohol on serum fluphenazine levels in stable chronic schizophrenics
Author(s) -
Soni S. D.,
Bamrah J. S.,
Krska J.
Publication year - 1991
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470060406
Subject(s) - fluphenazine , prolactin , alcohol , ingestion , medicine , placebo , anesthesia , ethanol , serum concentration , chemistry , hormone , biochemistry , alternative medicine , organic chemistry , pathology , haloperidol , dopamine
Seven chronic schizophrenic patients, stable for over 12 months on maintenance fluphenazine decanoate, were administered 40 g of alcohol orally soon after their regular injection. Blood samples for estimation of serum neuroleptic and prolactin levels were collected at various intervals over a 12 h period. The procedure was repeated at their next regular injection but without alcohol. It was found that alcohol ingestion produced a significant drop in both serum neuroleptic and prolactin levels which persisted during the study period.