Premium
Moclobemide pharmacokinetics in depressed patients: Lack of age effect
Author(s) -
Maguire K.,
Pereira A.,
Tiller J.
Publication year - 1991
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470060308
Subject(s) - moclobemide , pharmacokinetics , volume of distribution , tricyclic , medicine , depression (economics) , pseudoephedrine , pharmacology , antidepressant , ephedrine , macroeconomics , hippocampus , economics
The pharmacokinetics of moclobemide were examined in 19 depressed patients following a single oral dose of 50 mg. Ten patients were aged >60 years and nine <59 years. Plasma concentrations were analysed by gas chromatography with nitrogen‐specific detection. Pharmacokinetic parameters calculated were peak concentration, time to reach the peak, terminal disposition half‐life, area under the curve, oral clearance and apparent volume of distribution. No clinically significant differences were found betwen the two patient groups for these parameters. Thus there is no requirement for dosage adjustment in the older patient for moclobemide. This contrasts with some tricyclic and tetracyclic antidepressants which show significant age effects. Further studies of moclobemide for the treatment of elderly depression are warranted.