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Irritability in panic disorder: Effects of imipramine treatment
Author(s) -
Nutt D. J.,
Glue P.
Publication year - 1991
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470060109
Subject(s) - irritability , imipramine , panic , anxiety , panic disorder , depression (economics) , psychology , psychiatry , clinical psychology , medicine , alternative medicine , pathology , economics , macroeconomics
To establish the presence and magnitude of irritability in panic disorder, and its relationship with anxiety and depression, ratings of each variable were monitored in 18 patients with panic disorder before and during imipramine treatment. Pretreatment ratings of inward‐and outward‐directed irritability demonstrated borderline levels of morbidity. Over the duration of treatment, irritability ratings fell, and there were substantial reductions in ratings of depression, but only small reductions in ratings of state anxiety. There were a number of significant correlations between pre‐ and post‐treatment ratings of irritability and depression, but little association between these and ratings of anxiety.