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Comparison of mianserin and dothiepin treatment on the serotonergic system in depressed patients
Author(s) -
Butler J.,
Leonard B. E.
Publication year - 1990
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470050410
Subject(s) - mianserin , ketanserin , serotonergic , significant difference , medicine , platelet aggregation , pharmacology , serotonin , platelet , anesthesia , endocrinology , 5 ht receptor , receptor
Depressed patients showed a decreased 5‐HT uptake rate and aggregation response and increased platelet ketanserin binding, compared to normal controls. Five weeks treatment with either mianserin or dothiepin improved the biochemical parameters in the patients, although the parameters still had not returned to control levels. There was no difference between the biochemical markers in the mianserin and dothiepin groups at any time during the study.