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Effects of tranylcypromine on serotonin content and monoamine oxidase activitity of the human blood platelet
Author(s) -
Oxenkrug Gregory F.,
Balon Richard,
McCauley Roy B.,
McIntyre Iain M.
Publication year - 1990
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470050208
Subject(s) - tranylcypromine , serotonin , platelet , monoamine oxidase , antidepressant , chemistry , endocrinology , monoamine oxidase b , monoamine neurotransmitter , medicine , pharmacology , biochemistry , enzyme , receptor , hippocampus
Inhibition (>80 per cent) of platelet monoamine oxidase (MAO‐B type) and and an increase of platelet serotonin content were observed after tranylcypromine administration. It is suggested that the increase in platelet serotonin reflects MAO‐A inhibition, which may be correlated with antidepressant and hypotensive effects of MAO inhibitors.