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Metabolism of the benzodiazepine antagonist 11 C‐Ro 15‐1788 after intravenous administration in man
Author(s) -
Swahn CarlGunnar,
Persson Anders,
Pauli Stefan
Publication year - 1989
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470040410
Subject(s) - benzodiazepine , antagonist , chemistry , metabolism , positron emission tomography , pharmacology , pharmacokinetics , endocrinology , nuclear medicine , biochemistry , medicine , receptor
The metabolic fate of the benzodiazepine antagonist RO 15‐1788 labelled with 11 C was studied in plasma from human subjects after intravenous administration in connection with positron emission tomography. Ro 15–1788 and its metabolites were separated by thin‐layer chromatography and the radioactivity in the different compounds was determined. 11 C‐Ro 15–1788 was extensively and rapidly metabolised to the corresponding free acid. At 36 minutes after administration only 50% of the radioactivity in plasma represented unchanged compound.