Premium
The effects of lormetazepam on aspects of memory, sleep and human performance
Author(s) -
Dye Louise,
Alford C.,
Bhatti J. Z.,
Hindmarch I.
Publication year - 1989
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470040406
Subject(s) - flicker fusion threshold , anesthesia , triazolam , lorazepam , hypnotic , placebo , sedation , psychology , medicine , benzodiazepine , flicker , receptor , alternative medicine , pathology , electrical engineering , engineering
The effects of lormetazepam 1 mg, 1·5 mg, 2 mg, a verum—triazolam 0·5 mg and placebo were examined in ten normal female volunteers, on tests of psychomotor function, performance and analogue rating scales for subjective sedation, sleep and early morning behaviour. Results showed all doses of lormetazepam to be effective hypnotics and free from residual effects 10 h after drug ingestion when tested on critical flicker fusion threshold (CFF), choice reaction time (CRT), simultated car tracking task and Maddox wing. Acquisition and immediate recall of word lists was poorer following administration of lormetazepam 1·5 mg and triazolam 0·5 mg. On memory scanning, lormetazepam 1 mg was the only dose completely free from residual impairment 10 h following administration.