Stimulation of growth hormone secretion by baclofen in man: Failure to confirm published findings | Zendy

Markar Hameen | Zendy; Bennie John | Zendy; Carroll Sheena | Zendy; Chiswick Ann | Zendy; Wilson Helen | Zendy; Goodwin Guy M. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Stimulation of growth hormone secretion by baclofen in man: Failure to confirm published findings

Author(s) -

Markar Hameen,

Bennie John,

Carroll Sheena,

Chiswick Ann,

Wilson Helen,

Goodwin Guy M.

Publication year - 1989

Publication title -

human psychopharmacology: clinical and experimental

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.461

H-Index - 78

eISSN - 1099-1077

pISSN - 0885-6222

DOI - 10.1002/hup.470040209

Subject(s) - baclofen , stimulation , secretion , endocrinology , medicine , hormone , growth hormone , ingestion , agonist , receptor

The effects upon growth hormone (GH) secretion of oral baclofen were determined in 20 male volunteers. Doses of either 5 mg or 0·25 mg/kg (approx. 20 mg) of baclofen were employed. No stimulation of growth hormone secretion could be discerned in the 90 min following ingestion, a result which is in contrast with the findings of a previous study. We conclude that stimulation of GH secretion by baclofen at low doses does not provide a ready assay of GABA B function in man.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research