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Stimulation of growth hormone secretion by baclofen in man: Failure to confirm published findings
Author(s) -
Markar Hameen,
Bennie John,
Carroll Sheena,
Chiswick Ann,
Wilson Helen,
Goodwin Guy M.
Publication year - 1989
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470040209
Subject(s) - baclofen , stimulation , secretion , endocrinology , medicine , hormone , growth hormone , ingestion , agonist , receptor
The effects upon growth hormone (GH) secretion of oral baclofen were determined in 20 male volunteers. Doses of either 5 mg or 0·25 mg/kg (approx. 20 mg) of baclofen were employed. No stimulation of growth hormone secretion could be discerned in the 90 min following ingestion, a result which is in contrast with the findings of a previous study. We conclude that stimulation of GH secretion by baclofen at low doses does not provide a ready assay of GABA B function in man.