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Antidepressant drugs given repeatedly increase the behavioural effects of methoxamine
Author(s) -
Maj J.,
Rogóz̊ Z.,
Skuza G.
Publication year - 1989
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470040112
Subject(s) - methoxamine , open field , mianserin , imipramine , antidepressant , mirtazapine , pharmacology , neophobia , psychology , antagonist , agonist , medicine , anesthesia , psychiatry , receptor , hippocampus , alternative medicine , pathology
In this study we investigated the effect of imipramine, citalopram and mianserin on behavioural effects of methoxamine, an α 1 ‐adrenoceptor agonist, in the rat. Methoxamine (25 and 50 m̈g) given into the brain lateral ventricle, increases the exploratory activity assessed in the open field test (time of walking, ambulatory activity, rearing + peeping). The studied antidepressants, administered repeatedly (10 mg/kg p.o., twice daily, 14 days) but not in single doses, enhance the above effects of methoxamine. The results provide further arguments for the hypothesis that antidepressant drugs administered repeatedly induce a functional α 1 ‐adrenoceptor up‐regulation.