Premium
Aspects of alpha‐2‐adrenoceptor function in normal volunteers
Author(s) -
Nutt David J.,
Glue Paul
Publication year - 1988
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470030403
Subject(s) - clonidine , alpha (finance) , saline , alpha 2 adrenergic receptor , medicine , anesthesia , surgery , internal consistency , receptor , patient satisfaction
An intravenous infusion of clonidine (1.5 m̈g/kg) was given to 22 healthy male volunteers to establish normal hormonal biochemical, cardiovascular and psychological responses. Control data were provided by 12 of these subjects who had additional saline infusions, and repeat clonidine infusions were carried out in six subjects to assess test–retest reliability. Clonidine infusion appears to be a safe, reproducible and acceptable means of assessing alpha‐2‐adrenoceptor function in man.