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A psychopharmacological study to assess anti‐muscarinic and central nervous effects of medifoxamine in normal volunteers
Author(s) -
Randhawa M. A.,
Hedges A.,
Johnston A.,
Turner P.
Publication year - 1988
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470030307
Subject(s) - atropine , anesthesia , amitriptyline , placebo , alertness , flicker fusion threshold , medicine , latin square , psychology , pharmacology , chemistry , flicker , alternative medicine , pathology , electrical engineering , engineering , rumen , food science , fermentation
Ten volunteers received single oral doses of medifoxamine 50 and 100 mg, atropine 1 mg, amitriptyline 50 mg or placebo in random order based on a Latin square design under double‐blind conditions. Tests of anti‐muscarinic and central nervous activity were carried out at hourly intervals for 6 hours. The tests were measurements of salivary volume, heart rate, pupil diameter, manual dexterity, choice reaction time, critical flicker frequency, and visual analogue rating scales for sedation, dryness of mouth, appetite, nausea and quality of sleep. The positive controls atropine and amitriptyline produced effects which were significantly different from placebo, but neither dose of medifoxamine produced any anti‐muscarinic activity nor influenced alertness.