Premium
Heart rate response to standing as an index of adaptation to imipramine during treatment of panic disorder
Author(s) -
Middleton H. C.,
Nutt D. J.
Publication year - 1988
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470030306
Subject(s) - imipramine , heart rate , blood pressure , panic , panic disorder , orthostatic vital signs , tricyclic , medicine , tricyclic antidepressant , antidepressant , psychology , anesthesia , cardiology , psychiatry , pharmacology , anxiety , hippocampus , alternative medicine , pathology
The heart rate and blood pressure response to standing in eight patients receiving imipramine treatment for panic disorder were compared with the same measures in eight normal subjects after a single large dose. Despite higher plasma drug levels, patients on long‐term medication had a less abnormal orthostatic response than volunteers. This suggests that the heart rate response to standing could be a useful index of the neuropharmacological adaptation known to occur during administration of therapeutic doses of tricyclic antidepressant.