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Convulsant actions of the anxiolytic buspirone in combination with antidepressants
Author(s) -
File Sandra E.
Publication year - 1988
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470030212
Subject(s) - buspirone , maprotiline , mianserin , clomipramine , desipramine , anxiolytic , pharmacology , medicine , antidepressant , anesthesia , psychology , psychiatry , agonist , anxiety , receptor
The anxiolytic, buspirone, was given to rats in combination with four antidepressants: clomipramine (3–30 mg/g), desipramine (5–10 mg/kg), maprotiline (5–15 mg/kg) and mianserin (10–15 mg/kg). Even 2 mg/kg buspirone caused a significant incidence of myoclonic seizures, when combined with clomipramine (30 mg/kg), desipramine (5–10 mg/kg) and mianserin (15 mg/kg). Higher doses of buspirone caused seizures when combined with all doses of the four antidepressants tested. The only antidepressant to cause myoclonus on its own was maprotiline (10 and 15 mg/kg). The university of the incidence of myoclonus precluded any conclusions about the underlying mechnaism. However, whilst it is difficult to draw cross‐species conclusions, our results would caution against the clinical use of buspirone in combination with antidepressants.