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The psychopharmacological effects of single doses of prolonged release formulations of dimethindene and chlorpheniramine in human volunteers
Author(s) -
Lee Anthony,
Lader Malcolm,
Kitler Mary Ellen
Publication year - 1988
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470030207
Subject(s) - chlorpheniramine maleate , crossover study , anesthesia , chemistry , placebo , pharmacology , medicine , chromatography , alternative medicine , pathology
1. The effects of single doses of dimethindene (retard) 2·5 mg, chlorpheniramine (TD) 12mg and placebo on a battery of physiological, performance and subjective measures were studied in a double‐blind, crossover study in 12 healthy subjects. 2. Dimethindene had a different EEG profile from chlorpheniramine; while both active drug treatments were associated with an increase in 8·0–13·0 Hz waveband activity, dimethindene alone produced less 2·0–4·0 Hz activity. 3. The two active drugs were associated with an improvement in tapping rate. Dimethindene had no effect on simple reaction time, while chlorpheniramine was associated with a slowing in this measure. 4. Subjective measures generally indicated an improvement in general alertness and contentedness with both dimethindene and chlorpheniramine. 5. It is concluded that single doses of sustained‐release formulations of these antihistamines are slightly stimulant in effect and are useful where sedation in unacceptable.