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Hypotension and bradycardia induced by amitriptyline in healthy volunteers
Author(s) -
Curry Stephen H.,
Devane C. Lindsay,
Wolfe M. Michael
Publication year - 1988
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470030108
Subject(s) - lethargy , amitriptyline , bradycardia , tachycardia , anesthesia , medicine , blood pressure , heart rate
Seventeen healthy volunters in three groups received no treatment, or 25 or 50 mg doses of amitriptyline. Maximal measured concentrations of amitriptyline occurred at 4 h post‐dosage. There was a dose‐dependent change in performance of a digit symbol substitution test. Visual analogue scales measuring drowsiness, speed of thinking, and lethargy were sensitive to the drug. The low dose induced no blood pressure changes, but tachycardia occurred. The higher dose induced hypotension with bradycardia, a hitherto undocumented reaction to the drug.