Premium
Urinary cyclic AMP response to bovine parathyroid hormone during treatment with neuroleptics
Author(s) -
Waller Derek G.,
Albano Janet D. M.,
Guyedwards J.
Publication year - 1987
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470020205
Subject(s) - endocrinology , medicine , vasopressin , parathyroid hormone , arginine , urinary system , cyclase , adenylate kinase , hormone , chemistry , amino acid , calcium , biochemistry , receptor
The urinary cyclic AMP response to bovine parathyroid hormone and urinary concentrating ability (max Uosm) after des‐amino‐ D ‐arginine vasopressin were studies in nine volunteers and seven patients receiving long‐term neuroleptic treatment. Max Uosm was lower in the patient group (770 ± 70 mosmol/kg) compared with the controls (948 ± 152 mosmol/kg) but the trend to a lower cAMP response to bovine PTH was not statistically significant. These results suggest that, although adenylate cyclase inhibition may contribute, other mechanisms are also important in the genesis of reduced uring concentrating ability in patients treated with psychotropic drugs.