Premium
A case of triazolam abuse
Author(s) -
Kuniyoshi M.,
Arikawa K.,
Miura C.,
Nakamura J.,
Inanaga K.
Publication year - 1987
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.470020108
Subject(s) - triazolam , benzodiazepine , nitrazepam , physical dependence , anxiety , anesthesia , psychology , psychic , psychiatry , medicine , diazepam , receptor , alternative medicine , morphine , pathology
A case of abuse of triazolam, a short‐acting benzodiazepine, was experienced. A 35‐year‐old male, with a tendency to mixed drug dependence with nitrazepam, etc., and a background of neurotic anxiety and insomnia, started self‐administration of triazolam. Application of triazolam was frequent, with large doses up to a maximum of 80 mg/day (320 times the recommended daily dose of 250 micrograms). In addition to psychic dependence, occurrence of withdrawal symptoms confirmed formation of physical dependence, which was also supported by EEG together with the appearance of various autonomic and psychic symptoms. Even though triazolam is known to be comparatively safe, this case confirms that it can induce physical dependence upon frequent administration of a large amount, together with psychic dependence, and therefore care must be taken with regard to dosage. In particular, self‐administration of the drug should be strictly controlled.