(Des‐tyr 1 )‐gamma‐endorphin (DTγE) in the treatment of depression: Double‐blind placebo‐controlled trial | Zendy

Manchanda Rahul | Zendy; Hirsch Steven | Zendy

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(Des‐tyr 1 )‐gamma‐endorphin (DTγE) in the treatment of depression: Double‐blind placebo‐controlled trial

Author(s) -

Manchanda Rahul,

Hirsch Steven

Publication year - 1986

Publication title -

human psychopharmacology: clinical and experimental

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.461

H-Index - 78

eISSN - 1099-1077

pISSN - 0885-6222

DOI - 10.1002/hup.470010207

Subject(s) - placebo , rating scale , double blind , medicine , psychology , depression (economics) , mood , psychiatry , developmental psychology , alternative medicine , pathology , economics , macroeconomics

Preliminary evidence of a mood‐elevating effect for the endogenous neuropeptide, (des‐tyr 1 )‐gamma‐endorphin, was further investigated in a double‐blind placebo‐controlled trial over a period of 2 weeks. There were 10 patients in each group. Between‐group comparisons on the change in scores by day 14 were non‐significant. There was, however, a significant reduction ( p = 0.05, two‐tailed) of scores on the Montgomery Asberg Depression Rating Scale and the anxious‐depression subscale of the BPRS in the endorphin group. It is recommended that the trial be conducted in a larger sample for definitive results.

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