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Dextro‐amphetamine increases phosphoinositol cycle activity in volunteers: an MRS study
Author(s) -
Silverstone Peter H.,
O'Donnell Tina,
Ulrich Michele,
Asghar Sheila,
Hanstock Christopher C.
Publication year - 2002
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.434
Subject(s) - amphetamine , phosphomonoesters , dopamine , endocrinology , medicine , energy metabolism , phosphocreatine
Abstract Aims To help determine the effects of dextro‐amphetamine on the phosphoinositol cycle (PI‐cycle) in humans, 1 H and 31 P magnetic resonance spectroscopy (MRS) was utilized in 17 healthy volunteers. This was an open‐label study carried out before and after administration of 20 mg oral dextro‐amphetamine. Subjects also rated the subjective effects of dextro‐amphetamine administration using visual analog scales (VAS). Major findings Following dextro‐amphetamine administration there was a significant increase in the concentrations of both myo ‐inositol and phosphomonoesters. Conclusions These findings are in keeping with suggestions that dextro‐amphetamine administration increases the activity of the phosphoinositol cycle, probably via an indirect release of dopamine and noradrenaline. These results are the first time that this has been confirmed in humans. Copyright © 2002 John Wiley & Sons, Ltd.