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Effects of mirtazapine in patients with post‐traumatic stress disorder in Korea: a pilot study
Author(s) -
Bahk WonMyong,
Pae ChiUn,
Tsoh Joshua,
Chae JeongHo,
Jun TaeYoun,
Kim KwangSoo
Publication year - 2002
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.426
Subject(s) - mirtazapine , tolerability , rating scale , placebo , traumatic stress , psychology , antidepressant , depression (economics) , psychiatry , medicine , adverse effect , anxiety , developmental psychology , alternative medicine , pathology , macroeconomics , economics
This study was aimed at testing the efficacy and tolerability of mirtazapine in the treatment of Korean patients with chronic post‐traumatic stress disorder (PTSD). Mirtazapine was administered for 8 weeks using a flexible‐dose regime in 15 Korean patients with PTSD based on the DSM‐IV criteria. We evaluated the patients at baseline and at weeks 4 and 8 after treatment with the interviewer‐administered structured interview for PTSD (SIP), short PTSD rating interview (SPRINT), impact of event scale‐revised (IES‐R) and the Montgomery Åsberg depression rating scale (MADRS). Scores on the SIP, SPRINT, IES‐R and MADRS had significantly reduced after 8 weeks treatment. In this pilot study, mirtazapine was found to be effective and well tolerated in the treatment of patients with PTSD. This calls for further evaluation of the effect of this drug on subjects with PTSD with randomized placebo‐controlled studies. Copyright © 2002 John Wiley & Sons, Ltd.