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Driving performance and neurocognitive skills of long‐term users of sedating antidepressants
Author(s) -
van der Sluiszen Nick N.J.J.M.,
Vermeeren Annemiek,
van Dijken Joke H.,
J.A.E. van de Loo Aurora,
Veldstra Janet L.,
de Waard Dick,
C. Verster Joris,
A. Brookhuis Karel,
Ramaekers Johannes G.
Publication year - 2021
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.2762
Subject(s) - neurocognitive , term (time) , psychology , cognitive psychology , medicine , neuroscience , physical medicine and rehabilitation , psychiatry , cognition , physics , quantum mechanics
Objective To assess driving performance and neurocognitive skills of long‐term users of sedating antidepressants, in comparison to healthy controls. Methods Thirty‐eight long‐term (>6 months) users of amitriptyline ( n = 13) and mirtazapine ( n = 25) were compared to 65 healthy controls. Driving performance was assessed using a 1‐h standardised highway driving test in actual traffic, with road‐tracking error (standard deviation of lateral position [SDLP]) being the primary measure. Secondary measures included neurocognitive tasks related to driving. Performance differences between groups were compared to those of blood alcohol concentrations of 0.5 mg/ml to determine clinical relevance. Results Compared to controls, mean increase in SDLP of all antidepressant users was not significant, nor clinically relevant (+0.75 cm, 95% CI: −0.83 cm; +2.33 cm). However, users treated less than 3 years ( n = 20) did show a significant and clinically relevant increase in SDLP (+2.05 cm). No significant effects were observed on neurocognitive tasks for any user group, although large individual differences were present. Most results from neurocognitive tests were inconclusive, while a few parameters confirmed non‐inferiority for users treated longer than 3 years. Conclusion The impairing effects of antidepressant treatment on driving performance and neurocognition mitigate over time following long‐term use of 3 years.