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ABCB1 and CYP2D6 polymorphisms and treatment response of psychotic patients in a naturalistic setting
Author(s) -
Papazisis Georgios,
Goulas Antonios,
Sarrigiannidis Alexios,
Bargiota Stavroula,
Antoniadis Diomidis,
Raikos Nikolaos,
Basgiouraki Emmanouela,
Bozikas Vasileios P.,
Garyfallos Georgios
Publication year - 2018
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.2644
Subject(s) - cyp2d6 , genotyping , medicine , chlorpromazine , dose , genotype , antipsychotic , positive and negative syndrome scale , rating scale , schizophrenia (object oriented programming) , brief psychiatric rating scale , polymorphism (computer science) , allele , pharmacogenetics , psychosis , psychiatry , gastroenterology , clinical psychology , psychology , genetics , biology , cytochrome p450 , developmental psychology , metabolism , gene
Objectives The aim of our study was to examine the association between ABCB1 polymorphisms G2677T/A (rs2032582) and C3435T (rs1045642) and common CYP2D6 variants, with the response to antipsychotic treatment of psychotic patients, in a naturalistic setting, in Greece. Methods One hundred patients suffering from schizophrenia and other psychotic disorders were included in the study. Dosages were normalized to chlorpromazine equivalents. Response following 1 month of treatment was assessed as either a continuous variable, using the distribution of the corrected Positive and Negative Syndrome Scale percent change, or as a dichotomous variable defined as the number of patients scoring ≥30% from the corrected baseline Positive and Negative Syndrome Scale score. Genotyping was achieved with established polymerase chain reaction–restriction fragment length polymorphism methods. Results With response treated as a continuous variable, the homozygous recessive rs2032582 genotypes (TT) who were simultaneously carriers of a loss‐of‐function CYP2D6 allele (*4 or *5) responded significantly worse than the rest of the patients. Comparison of genotype frequencies revealed a statistically significant association of the above combination. No significant association between chlorpromazine equivalents and the tested genotypes was detected. Conclusion We have detected a possible interaction between ABCB1 and CYP2D6 in affecting response of psychotic patients to drug treatment, in a naturalistic setting.