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Association study between the neurexin‐1 gene and tardive dyskinesia
Author(s) -
Lanning Rachel,
Lett Tristram A.,
Tiwari Arun K.,
Brandl Eva J.,
Luca Vincenzo,
Voineskos Aristotle N.,
Potkin Steven G.,
Lieberman Jeffrey A.,
Meltzer Herbert Y.,
Müller Daniel J.,
Remington Gary,
Kennedy James L.,
Zai Clement C.
Publication year - 2017
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.2568
Subject(s) - tardive dyskinesia , neurexin , single nucleotide polymorphism , dyskinesia , schizophrenia (object oriented programming) , antipsychotic , medicine , gene , bioinformatics , genetics , psychiatry , neuroscience , biology , genotype , receptor , parkinson's disease , postsynaptic potential , disease
Objective Tardive dyskinesia (TD) is a motor side effect that may develop after long‐term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin‐1 ( NRXN1 ) gene that codes for a cell adhesion molecule in synaptic communication. Methods This study examined five NRXN1 single‐nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry. Results We did not find these SNPs to be significantly associated with TD. Conclusions More research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.