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Haloperidol increases false recognition memory of thematically related pictures in healthy volunteers
Author(s) -
Guarnieri Regina V.,
Buratto Luciano G.,
Gomes Carlos F.A.,
Ribeiro Rafaela L.,
Souza Altay A. Lino,
Stein Lilian M.,
Galduróz José C.,
Bueno Orlando F.A.
Publication year - 2017
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.2563
Subject(s) - haloperidol , placebo , psychology , dopamine antagonist , dopamine , recognition memory , antagonist , blockade , episodic memory , medicine , neuroscience , audiology , receptor , cognition , alternative medicine , pathology
Dopamine can modulate long‐term episodic memory. Its potential role on the generation of false memories, however, is less well known. In a randomized, double‐blind, placebo‐controlled experiment, 24 young healthy volunteers ingested a 4‐mg oral dose of haloperidol, a dopamine D 2 ‐receptor antagonist, or placebo, before taking part in a recognition memory task. Haloperidol was active during both study and test phases of the experiment. Participants in the haloperidol group produced more false recognition responses than those in the placebo group, despite similar levels of correct recognition. These findings show that dopamine blockade in healthy volunteers can specifically increase false recognition memory.