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Nicotine administration in healthy non‐smokers reduces appetite but does not alter plasma ghrelin
Author(s) -
Pilhatsch Maximilian,
Scheuing Hannah,
Kroemer Nils,
Kobiella Andrea,
Bidlingmaier Martin,
Farger Gisbert,
Smolka Michael N.,
Zimmermann Ulrich S.
Publication year - 2014
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.2405
Subject(s) - orexigenic , ghrelin , appetite , nicotine , medicine , endocrinology , crossover study , smoking cessation , hormone , neuropeptide y receptor , neuropeptide , receptor , alternative medicine , pathology , placebo
Objective We studied whether suppressed secretion of the orexigenic peptide ghrelin might be involved in the anorexigenic effects of nicotine. Methods Fifty healthy non‐smokers chewed gums containing 2 mg nicotine, or no nicotine in a double‐blind randomised crossover design in two independent studies. Results Plasma nonacylated ghrelin was not significantly affected by nicotine after 30 and 60 min. Increased blood pressure and decreased appetite ratings confirmed a biological nicotine effect. Conclusions These results do not support a key role of peripheral ghrelin secretion in weight changes related to smoking or smoking cessation, but do not rule out that central nervous system ghrelin is involved. Copyright © 2014 John Wiley & Sons, Ltd.