Premium
Novel pharmacological agents targeting memory and cognition in the treatment of anxiety disorders
Author(s) -
Nandhra Harpal Singh,
Murphy Catherine Louise,
Sule Akeem
Publication year - 2013
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.2348
Subject(s) - anxiety , memantine , memory consolidation , cognition , riluzole , psychology , medicine , neuroscience , psychiatry , pharmacology , glutamate receptor , dementia , hippocampus , receptor , disease
Objective The aim of this study is to review data for several promising novel pharmacological drugs for anxiety disorders and describe how they exert their effects. Method We presented a review of the published literature. Online search plus reference list checking was also used. Results The neurobiology of anxiety is overviewed. N‐methyl‐D‐aspartate and beta adrenaline are involved in memory consolidation. We describe studies using memantine, D‐cycloserine, propranolol, and riluzole that modulate these pathways. Conclusion There are a number of promising new therapies, but these require further studies before they can enter routine clinical practice. Copyright © 2013 John Wiley & Sons, Ltd.