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Substitutional potential of mephedrone: an analysis of the subjective effects
Author(s) -
KapitányFövény Máté,
Kertész Máté,
Winstock Adam,
Deluca Paolo,
Corazza Ornella,
Farkas Judit,
Zacher Gábor,
Urbán Róbert,
Demetrovics Zsolt
Publication year - 2013
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.2297
Subject(s) - mephedrone , mdma , ecstasy , psychology , cathinone , stimulant , clinical psychology , psychiatry , drug , amphetamine , neuroscience , dopamine
Objective In the past 25–30 years, a large number of synthetic and non‐synthetic drugs have appeared on the recreational scene, but with the exception of 4‐methylmethcathinone (mephedrone), none of these substances reached the popularity of ecstasy [3,4‐methylenedioxy‐N‐methylamphetamine, (MDMA)]. Authors aimed to determine the subjective effects of mephedrone in order to understand how mephedrone can serve as a potential substitute for entactogens, such as MDMA. Methods One hundred forty‐five mephedrone users—recruited by snowball method—filled out a questionnaire on their patterns of use and experienced subjective effects of mephedrone. Results Factor analysis revealed six factors of mephedrone‐induced subjective effects: positive emotions, sensibility, adverse somatic effects, adverse psychological effects, stimulant effects, and psychedelic effects. A preference list of subjective effects indicates that mephedrone is popular primarily for its psychostimulant and entactogen effects. Latent class analysis identified two classes of mephedrone users, with closely parallel profiles. The two classes differed in severity of subjective experience in a way that was consistent across the six dimensions. Conclusions By having similar subjective effects as MDMA and other entactogens, mephedrone seems able to substitute other enactogenic stimulants. Copyright © 2013 John Wiley & Sons, Ltd.