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The BTBD9 gene may be associated with antipsychotic‐induced restless legs syndrome in schizophrenia
Author(s) -
Kang SeungGul,
Lee HeonJeong,
Park YoungMin,
Yang Hee Jung,
Song Hyun Mi,
Lee Yu Jin,
Cho SeongJin,
Cho Sung Nam,
Kim Leen
Publication year - 2013
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.2287
Subject(s) - restless legs syndrome , haplotype , genotype , single nucleotide polymorphism , medicine , antipsychotic , polymorphism (computer science) , schizophrenia (object oriented programming) , allele , psychosis , neuroleptic malignant syndrome , gastroenterology , psychiatry , genetics , gene , biology , neurology
Objective A genome‐wide association study and several replication studies have shown significant association between BTBD9 gene single nucleotide polymorphisms and restless legs syndrome (RLS). The aim of this study is to investigate the association between the BTBD9 gene polymorphisms and antipsychotic‐induced RLS in schizophrenic patients. Methods Restless legs syndrome symptoms were evaluated using the diagnostic criteria of the International Restless Legs Syndrome Study Group in 190 Korean schizophrenic patients. We genotyped the rs9357271 and rs3923809 polymorphisms of the BTBD9 gene in schizophrenic patients with ( n = 96) and without ( n = 94) RLS symptoms. Results There was a significant difference in the allele frequency ( χ 2 = 8.14, p = 0.004) of the rs9357271 polymorphism between schizophrenic patients with and without RLS symptoms. Significant genotypic association of this single nucleotide polymorphisms with RLS symptoms was also observed for the dominant model ( χ 2 = 10.32, p = 0.001) and heterozygous model ( χ 2 = 10.9, p = 0.001). When we compared the frequencies of the rs3923809–rs9357271 haplotypes between the two groups, the overall haplotype frequencies were significantly different (permuted p = 0.037), and the A‐T haplotype was significantly more frequent in the RLS symptom group than in the no RLS symptom group (0.112 vs. 0.041, permuted p = 0.007). Conclusions These data suggest that the BTBD9 gene is associated with antipsychotic‐induced RLS symptoms in schizophrenic patients. Copyright © 2013 John Wiley & Sons, Ltd.