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Effects of olanzapine on 31 P MRS metabolic markers in schizophrenia
Author(s) -
Nenadic Igor,
Dietzek Maren,
Langbein Kerstin,
Rzanny Reinhard,
Gussew Alexander,
Reichenbach Jürgen R.,
Sauer Heinrich,
Smesny Stefan
Publication year - 2013
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.2274
Subject(s) - olanzapine , schizophrenia (object oriented programming) , antipsychotic , medicine , endocrinology , adenosine triphosphate , cerebellum , phosphocreatine , energy metabolism , chemistry , pharmacology , psychiatry
Antipsychotic drug action might include mechanisms related to normalising phospholipid and high‐energy metabolism. We applied brain metabolic imaging with 31 P magnetic resonance spectroscopy ( 31 P MRS) and two‐dimensional chemical shift imaging to assess changes of metabolism of phospholipids and high‐energy phosphates in schizophrenia patients at baseline (four antipsychotic‐naïve and three off antipsychotics) and at follow‐up, after 6 weeks of treatment with olanzapine. Results indicate a significant increase of adenosine‐triphosphate (ATP) in the right inferior temporal cortex and a trend towards ATP decrease in the left cerebellum. This suggests a shift in high‐energy phosphates (rather than phospholipids), possibly related to normalisation of functioning in these areas. Copyright © 2012 John Wiley & Sons, Ltd.