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No association between the type 2 diabetes mellitus susceptibility gene, SLC30A8 and schizophrenia in a Chinese population
Author(s) -
Zhang Xuan,
Guan SongLei,
Wang ZhenQi,
You Yang,
Sun ShiLong,
Hui Li,
Miao Lining,
Yu Yaqin,
Kosten Thomas R,
Zhang Xiang Yang
Publication year - 2012
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.2239
Subject(s) - allele , schizophrenia (object oriented programming) , genotype , genetics , genetic association , polymorphism (computer science) , gene , biology , medicine , single nucleotide polymorphism , psychiatry
Background The co‐occurrence of schizophrenia and type 2 diabetes mellitus (T2DM) has been well documented. Recent genome‐wide association studies and meta‐analyses have shown robust associations of the solute carrier family 30 member 8 ( SLC30A8 ) gene variants with T2DM in various populations. We examined the involvement of the SLC30A8 in the susceptibility to schizophrenia in a Han Chinese population. Methods The SLC30A8 rs13266634 gene polymorphism was genotyped in 837 chronic schizophrenic and 1109 unrelated healthy controls by using a case control design. We also assessed clinical symptoms. Results There were no significant differences in the rs13266634 genotype ( χ 2 = 1.95, df = 2, p = 0.38) and allele ( χ 2 = 0.47, df = 1, p = 0.50) distributions between the patient and control groups. There was no association between rs13266634 and clinical symptoms. Conclusion The SLC30A8 gene variation does not appear to contribute a genetic basis for the co‐occurrence of schizophrenia and T2DM. Copyright © 2012 John Wiley & Sons, Ltd.