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No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia
Author(s) -
Ivanova Svetlana A.,
Al Hadithy Asmar F. Y.,
Brazovskaya Natalia,
Semke Arkadiy,
Wilffert Bob,
Fedorenko Olga,
Brouwers Jacobus R. B. J.,
Loonen Anton J. M.
Publication year - 2012
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.2226
Subject(s) - tardive dyskinesia , dyskinesia , adenosine a2a receptor , medicine , logistic regression , genotype , adenosine , psychiatry , psychology , anesthesia , receptor , adenosine receptor , schizophrenia (object oriented programming) , biology , genetics , gene , disease , parkinson's disease , agonist
Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross‐sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between‐group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia. Copyright © 2012 John Wiley & Sons, Ltd.