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Antidepressants in clinical practice: limitations of assessment methods and drug response
Author(s) -
Kennedy Sidney H,
Eisfeld Beata S,
Meyer Jeffrey H,
Bagby R Michael
Publication year - 2001
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.189
Subject(s) - clinical practice , drug trial , clinical trial , medicine , outcome (game theory) , randomized controlled trial , drug response , intensive care medicine , psychology , drug , psychiatry , physical therapy , mathematics , mathematical economics
There is a recognized gap between knowledge derived from ‘efficacy’ data — based on usually brief randomized controlled trials and findings in natural practice ‘effectiveness’ studies. In considering the limitations of current antidepressants in clinical practice, we have selected three clinically important issues to examine in a natural practice data base that has been in existence for several years. These relate to: (1) Diagnostic heterogeneity and potential advances using functional brain imaging; (2) Variability of outcome measures during treatment and (3) Time to response and prediction of outcome. Copyright © 2001 John Wiley & Sons, Ltd.