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Combination of antidepressant drugs: the case of inositol
Author(s) -
Nemets Boris,
Fux Mendel,
Levine Joseph,
Belmaker R. H
Publication year - 2001
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.181
Subject(s) - antidepressant , reuptake inhibitor , reuptake , monoamine oxidase , inositol , pharmacology , serotonin , serotonin reuptake inhibitor , depression (economics) , medicine , psychology , chemistry , psychiatry , receptor , biochemistry , enzyme , anxiety , macroeconomics , economics
Inositol is a second messenger precursor that is effective in depression and obsessive‐compulsive disorder via a mechanism different from serotonin reuptake inhibitors. However, controlled trials of inositol combined with serotonin reuptake inhibitors in depression or in reuptake inhibitor resistant depressed patients, or in partially responsive obsessive‐compulsive patients, did not reveal added benefit. This is comparable to results with combinations of other antidepressant treatments, such as tricyclics plus monoamine oxidase inhibitors. Copyright © 2001 John Wiley & Sons, Ltd.