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Retracted: Effect of blonanserin on cognitive function in antipsychotic‐naïve first‐episode schizophrenia
Author(s) -
Tenjin Tomomi,
Miyamoto Seiya,
Miyake Nobumi,
Ogino Shin,
Kitajima Rei,
Ojima Kazuaki,
Arai Jun,
Teramoto Haruki,
Tsukahara Sachiko,
Ito Yukie,
Tadokoro Masanori,
Anai Kiriko,
Funamoto Yasuyuki,
Kaneda Yasuhiro,
Sumiyoshi Tomiki,
Yamaguchi Noboru
Publication year - 2012
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.1276
Subject(s) - schizophrenia (object oriented programming) , verbal fluency test , psychology , cognition , antipsychotic , positive and negative syndrome scale , clinical global impression , psychiatry , audiology , clinical psychology , medicine , psychosis , neuropsychology , alternative medicine , pathology , placebo
Objective The purpose of this study was to evaluate the effects of blonanserin, a novel antipsychotic, on cognitive function in first‐episode schizophrenia. Methods Twenty‐four antipsychotic‐naïve patients with first‐episode schizophrenia participated in the study. Blonanserin was given in an open‐label design for 8 weeks. The Brief Assessment of Cognition in Schizophrenia—Japanese language version (BACS‐J) was administered as the primary outcome measure at baseline and 8 weeks. Clinical evaluation included the Positive and Negative Syndrome Scale (PANSS), the Schizophrenia Quality of Life Scale—Japanese language version (SQLS‐J), and the Clinical Global Impression—Severity of Illness Scale (CGI‐S). To exclude the possibility of retest effects on the BACS‐J, 10 age‐matched patients with chronic schizophrenia treated with blonanserin were tested at baseline and after an 8‐week interval. Results Twenty first‐episode patients completed the study. Repeated measures analysis of covariance revealed a significant group‐by‐time interaction effect on the letter fluency task due to better performance in the first‐episode group, but not in the control group. Main effect of time or group‐by‐time interaction effect on the Tower of London task was not significant; however, the first‐episode group, but not the control group, showed substantial improvement with a moderate effect size. All items on the PANSS, SQLS‐J, and CGI‐S significantly improved after 8 weeks of treatment. Conclusions These results suggest that blonanserin improves some types of cognitive function associated with prefrontal cortical function. Copyright © 2012 John Wiley & Sons, Ltd.