Premium
The prevalence and clinical‐demographic correlates of diabetes mellitus in chronic schizophrenic patients receiving clozapine
Author(s) -
Zhang Ruiling,
Hao Wei,
Pan Miao,
Wang Chuansheng,
Zhang Xiuli,
Chen Da Chun,
Xiu Mei Hong,
De Yang Fu,
Kosten Thomas R.,
Zhang Xiang Yang
Publication year - 2011
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.1220
Subject(s) - medicine , diabetes mellitus , body mass index , schizophrenia (object oriented programming) , odds ratio , clozapine , confidence interval , population , positive and negative syndrome scale , psychopathology , family history , psychiatry , psychosis , endocrinology , environmental health
Objective To examine the prevalence and correlates of diabetes in a large sample of Chinese patients with schizophrenia on long‐term clozapine treatment, because this population previously has received little systematic study. Methods Two hundred and six inpatients meeting Diagnostic and Statistical Manual of Mental Disorders, 4th Edition schizophrenia criteria were recruited in a cross‐sectional naturalistic study, and compared with 615 healthy control subjects matched for age, sex, education, and body mass index (BMI). The patient's psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS). Diagnoses of diabetes were established through review of medical records and fasting blood glucose testing, or an oral glucose tolerance test. Results Diabetes mellitus was more common in patients than in the normal controls (22.3% vs 6.2%) (odds ratio = 4.37, confidence interval (CI) 2.76–6.92, p < 0.001). The prevalence of diabetes increased with age across five age‐groups as compared with normal controls ( X 2 = 18.0, df = 4, p = 0.001). The PANSS total score and sub‐scores showed no differences between the diabetic and non‐diabetic groups. Logistic regression in the patients revealed significant associations between diabetes and a family history of diabetes ( p < 0.001), age ( p < 0.01), and BMI ( p < 0.05). Conclusion Long‐term clozapine treatment was associated with an increased and clinically important risk of diabetes mellitus in Chinese chronic schizophrenic patients, which is consistent with previous reports in Western populations. Copyright © 2011 John Wiley & Sons, Ltd.