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MAOA gene polymorphisms and response to mirtazapine in major depression
Author(s) -
Tzeng DongSheng,
Chien ChiaChang,
Lung ForWey,
Yang Chun Yuh
Publication year - 2009
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.1024
Subject(s) - mirtazapine , medicine , hamilton rating scale for depression , monoamine oxidase a , major depressive disorder , polymorphism (computer science) , gastroenterology , psychology , psychiatry , oncology , genotype , antidepressant , genetics , biology , gene , serotonin , receptor , amygdala , hippocampus
Abstract Background Polymorphisms in the monoamine oxidase A (MAOA) gene may influence treatment outcomes in major depression disorder (MDD). Objective To investigate the association of MAOA genetic polymorphisms and response to mirtazapine in patients with MDD. Method Fifty‐eight adult patients in Taiwan who met the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM‐IV) diagnostic criteria for MDD were given mirtazapine for 7 weeks and evaluated on days 0, 7, 14, 21, 49 using the 24‐item Hamilton Rating Scale for Depression (HRSD). Remission was defined as a final HRSD ≤ 10 and a 50% reduction in baseline HRSD score. Patients provided venous blood for DNA testing. The patients' response to mirtazapine treatment was compared between those who had the long‐form polymorphism in the MAOA gene promoter and the short‐form polymorphism. Result The total HRSD scores after mirtazapine treatment were significantly lower than baseline ( p < 0.001). There were 10 cases (38.5%) in short from and 6 (18.8%) in long from group touched the remission stage. Patients with the short‐form group had a greater response to mirtazapine ( p < 0.001) than those with the long‐form polymorphism after controlling for age, sex, and apolipoprotein E genetic (APOE) polymorphism. Conclusion The genetic polymorphisms in the MAOA promoter region may be associated with treatment response to mirtazapine. Copyright © 2009 John Wiley & Sons, Ltd.