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Non‐motor cognitive‐perceptual dysfunction associated with drug‐induced parkinsonism
Author(s) -
Kim JongHoon,
Byun HeeJung
Publication year - 2009
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/hup.1009
Subject(s) - cognition , psychology , parkinsonism , psychomotor learning , schizophrenia (object oriented programming) , perception , audiology , correlation , distress , motor dysfunction , clinical psychology , psychiatry , medicine , neuroscience , geometry , disease , mathematics
Objective The purpose of the present study was to examine the relationship between drug‐induced parkinsonism (DIP) and subjective non‐motor cognitive impairments in schizophrenia by performing comprehensive assessments of extrapyramidal side effects (EPS) and the subjective cognitive‐perceptual functioning. Methods Ninety‐one outpatients with schizophrenia were evaluated for DIP and other EPS. Subjective cognitive‐perceptual dysfunction was comprehensively assessed using the Frankfurt Complaint Questionnaire (FCQ). To examine the association between DIP and non‐motor cognitive‐perceptual dysfunction, Pearson's partial correlation analysis was performed between the FCQ scores and the severity of DIP, controlling for relevant variables. Results The analysis revealed that the severity of DIP had a significant correlation with the total FCQ score ( p < 0.05). In phenomenological subscales, the severity of DIP showed significant correlations with “deterioration of discrimination,” “psychomotor disorder,” “perceptual disorder,” “cognitive floating,” and “automatic behavior disorder” ( p < 0.05). Conclusions The results of our study suggest that DIP is significantly associated with a wide range of subjective non‐motor cognitive impairments. Clinicians should be careful of the appearance of DIP and the associated non‐motor cognitive‐perceptual symptoms, which may cause considerable distress and reduce the quality of life in an already vulnerable group of patients. Copyright © 2009 John Wiley & Sons, Ltd.