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A BRCA1 mutation in Native North American families
Author(s) -
Liede Alexander,
Jack Elaine,
Hegele Robert A.,
Narod Steven A.
Publication year - 2002
Publication title -
human mutation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 162
eISSN - 1098-1004
pISSN - 1059-7794
DOI - 10.1002/humu.9027
Subject(s) - biology , genetics , mutation , founder effect , native american , germline , germline mutation , genealogy , ethnic group , gene , allele , haplotype , anthropology , history , sociology
Germline mutations in the BRCA1 (MIM 113705) and BRCA2 (MIM 600185) genes have been identified for breast and ovarian cancer families of diverse ethnic backgrounds. To date, there have been no reports of Native North American families with mutations in BRCA1 or BRCA2. Here we report two families of aboriginal descent both with the same BRCA1 alterations (1510insG, 1506A>G). The families represent two aboriginal Canadian tribes (Cree and Ojibwe), although a common ancestral origin is likely. This is the first evidence of a BRCA1 mutation specific to aboriginal peoples of North America. © 2002 Wiley‐Liss, Inc.