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Quantitative mapping of genetic similarity in human heritable diseases by shared mutations
Author(s) -
Zhao Huiying,
Yang Yuedong,
Lu Yutong,
Mort Matthew,
Cooper David N.,
Zuo Zhiyi,
Zhou Yaoqi
Publication year - 2018
Publication title -
human mutation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 162
eISSN - 1098-1004
pISSN - 1059-7794
DOI - 10.1002/humu.23358
Subject(s) - biology , genetics , disease , mutation , heritability , missing heritability problem , gene , phenotype , genotype , genetic variants , medicine
Abstract Many genetic diseases exhibit considerable epidemiological comorbidity and common symptoms, which provokes debate about the extent of their etiological overlap. The rapid growth in the number of known disease‐causing mutations in the Human Gene Mutation Database (HGMD) has allowed us to characterize genetic similarities between diseases by ascertaining the extent to which identical genetic mutations are shared between diseases. Using this approach, we show that 41.6% of disease pairs in all possible pairs (42, 083) exhibit a significant sharing of mutations ( P value < 0.05). These mutation‐related disease pairs are in agreement with heritability‐based disease–disease relations in 48 neurological and psychiatric disease pairs (Spearman's correlation coefficient = 0.50; P value = 3.4 × 10 −5 ), and share over‐expressed genes significantly more often than unrelated disease pairs (1.5–1.8‐fold higher; P value ≤ 1.6 × 10 −4 ). The usefulness of mutation‐related disease pairs was further demonstrated for predicting novel mutations and identifying individuals susceptible to Crohn disease. Moreover, the mutation‐based disease network concurs closely with that based on phenotypes.