Premium
The rs2910164:G>C SNP in the MIR146A gene is not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
Author(s) -
Garcia Amandine I.,
Cox David G.,
Barjhoux Laure,
VernyPierre Carole,
Barnes Daniel,
Antoniou Antonis C.,
StoppaLyonnet Dominique,
Sinilnikova Olga M.,
Mazoyer Sylvie
Publication year - 2011
Publication title -
human mutation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 162
eISSN - 1098-1004
pISSN - 1059-7794
DOI - 10.1002/humu.21539
Subject(s) - snp , biology , breast cancer , single nucleotide polymorphism , ovarian cancer , mutation , genetics , gene , oncology , genotype , cancer , medicine
The rs2910164:G>C SNP is located in the gene for miR‐146a, a microRNA that binds the 3′ UTR of the BRCA1 transcript. Preliminary data based on the analysis of a small number of cases suggested that this single nucleotide polymorphism (SNP) might be associated with the age of onset of familial breast and ovarian cancer. This effect was not confirmed on a large series of familial breast cancer cases negative for a BRCA1 or BRCA2 mutation. We show here a lack of association of the rs2910164:G>C SNP with breast cancer risk in a series of 1,166 BRCA1 and 560 BRCA2 mutation carriers. In conclusion, the polymorphism in the miR‐146a gene is unlikely to be of substantial significance regarding breast cancer risk. Hum Mutat 32:1–4, 2011. © 2011 Wiley‐Liss, Inc.