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No association between CALHM1 variation and risk of Alzheimer disease
Author(s) -
Minster Ryan L.,
Demirci F. Yesim,
DeKosky Steven T.,
Kamboh M. Ilyas
Publication year - 2009
Publication title -
human mutation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 162
eISSN - 1098-1004
pISSN - 1059-7794
DOI - 10.1002/humu.20989
Subject(s) - allele , biology , disease , alzheimer's disease , genotype , genetic association , polymorphism (computer science) , genetics , degenerative disease , medicine , gene , single nucleotide polymorphism
A polymorphism in the calcium homeostasis modulator 1 gene ( CALHM1 ) has recently been associated with risk of late‐onset Alzheimer disease. We examined this variant ( rs2986017 ) in 945 Caucasian Americans with late‐onset Alzheimer disease and 875 age‐matched Caucasian American controls. No association with risk of late‐onset Alzheimer disease ( p =0.368 for genotypes; p =0.796 for alleles) was observed in our sample. However, a potential modest association of minor allele homozygosity (TT) with an earlier age‐at‐onset was seen ( p =0.034). © 2009 Wiley‐Liss, Inc.
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