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Human genome variation and pharmacogenetics
Author(s) -
Gottlieb Bruce
Publication year - 2008
Publication title -
human mutation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 162
eISSN - 1098-1004
pISSN - 1059-7794
DOI - 10.1002/humu.20728
Subject(s) - biology , pharmacogenomics , pharmacogenetics , human genome , variation (astronomy) , genome , genetic variation , computational biology , human genetics , genetics , evolutionary biology , gene , genotype , physics , astrophysics
Abstract A recent HGVS‐sponsored symposium has examined, for the first time, the possible effects of the discovery of very large and widespread amounts of human genome variation on the emerging fields of pharmacogenetics and pharmacogenomics. This article discusses the effects of the resultant paradigm shifts and raises a number of important questions that need to be considered in order to truly advance the field in a meaningful and significant way. Hum Mutat 29(4):453–455, 2008. © 2008 Wiley‐Liss, Inc.