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DNA damage detection and repair, and the involvement of epigenetic states
Author(s) -
Bassal Sahar,
ElOsta Assam
Publication year - 2005
Publication title -
human mutation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 162
eISSN - 1098-1004
pISSN - 1059-7794
DOI - 10.1002/humu.20130
Subject(s) - chromatin , biology , epigenetics , dna repair , genetics , computational biology , chromatin remodeling , dna , transcription (linguistics) , microbiology and biotechnology , gene , linguistics , philosophy
Abstract Chromatin is a highly dynamic structure that acts alternately as a substrate and a template in a number of critical biological processes. Modification of chromatin is pertinent and is responsible for a number of nuclear processes, including DNA repair, replication, transcription, and recombination. The purpose of this review is to discuss specific interactions between chromatin remodeling, DNA repair, and transcription. These areas are demonstrated to share commonality, particularly with a number of key molecules that appear to have roles in a number of pathways. The implications of pathway cross‐over and communication form a seamless continuation of genomic integrity and stability. Hum Mutat 25:101–109, 2005. © 2005 Wiley‐Liss, Inc.