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Three‐tiered noninvasive diagnosis in 96% of patients with Duchenne muscular dystrophy (DMD)
Author(s) -
Yan Jin,
Feng Jig,
Buzin Carolyn H.,
Scaringe William,
Liu Qiang,
Mendell Jerry R.,
Dunnen Johan den,
Sommer Steve S.
Publication year - 2004
Publication title -
human mutation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 162
eISSN - 1098-1004
pISSN - 1059-7794
DOI - 10.1002/humu.10307
Subject(s) - duchenne muscular dystrophy , biology , muscular dystrophy , content (measure theory) , computational biology , genetics , mathematics , mathematical analysis
A C 2-symmetrical aryl diphosphite derived from chiral binaphthol was prepared and its rhodium complex was used as catalysts in the asymmetric hydroformylation of olefins. High catalytic activity and good regioselectivity were observed. Up to 31.2% ee and 38.1% ee were achieved for the hydroformylation of 4-fluoro-styrene and vinyl acetate respectively. The influences of ligand-to-metal ratio, reaction temperature and the pressure of syn-gas on the enantioselectivity and regioselectivity were also studied.Department of Applied Biology and Chemical Technolog